refractory
adjective uk/rɪˈfræk.tər.i/ us/rɪˈfræk.tər.i/
medical, science specialized不应的，难治的
not affected by a treatment, change, or process
This is a chronic and disabling condition that is refractory to treatment. 这是一种慢性致残的症状，对治疗的反应不佳。
formal难以控制的;不听从的
difficult to control; unwilling to obey
a refractory child 不听话的孩子